100000 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 100010 - Statement - BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 100020 - Statement - BALANCE SHEETS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 100030 - Statement - STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS link:presentationLink link:calculationLink link:definitionLink 100040 - Statement - STATEMENTS OF STOCKHOLDERS' EQUITY link:presentationLink link:calculationLink link:definitionLink 100050 - Statement - STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 100060 - Disclosure - Organization and Operations link:presentationLink link:calculationLink link:definitionLink 100070 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 100080 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 100090 - Disclosure - Loss per Share link:presentationLink link:calculationLink link:definitionLink 100100 - Disclosure - Composition of Certain Financial Statement Captions link:presentationLink link:calculationLink link:definitionLink 100110 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 100120 - Disclosure - License Agreements link:presentationLink link:calculationLink link:definitionLink 100130 - Disclosure - Term Loan Obligations link:presentationLink link:calculationLink link:definitionLink 100140 - Disclosure - Grant Revenue link:presentationLink link:calculationLink link:definitionLink 100150 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 100160 - Disclosure - Employee Benefit Plan link:presentationLink link:calculationLink link:definitionLink 100170 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 100180 - Disclosure - Share-based Compensation link:presentationLink link:calculationLink link:definitionLink 100190 - Disclosure - Financial Statement Schedules link:presentationLink link:calculationLink link:definitionLink 100200 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 100210 - Disclosure - Loss per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 100220 - Disclosure - Composition of Certain Financial Statement Captions (Tables) link:presentationLink link:calculationLink link:definitionLink 100230 - Disclosure - Commitments and Contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 100240 - Disclosure - Term Loan Obligations (Tables) link:presentationLink link:calculationLink link:definitionLink 100250 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 100260 - Disclosure - Share-based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 100270 - Disclosure - Organization and Operations - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100280 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100290 - Disclosure - Fair Value Measurements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100300 - Disclosure - Loss per Share - Schedule of Antidilutive Securities Excluded from Diluted Income (Loss) per Share (Details) link:presentationLink link:calculationLink link:definitionLink 100310 - Disclosure - Composition of Certain Financial Statement Captions - Other Current Assets (Details) link:presentationLink link:calculationLink link:definitionLink 100320 - Disclosure - Composition of Certain Financial Statement Captions - Property and Equipment, Net (Details) link:presentationLink link:calculationLink link:definitionLink 100330 - Disclosure - Composition of Certain Financial Statement Captions - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100340 - Disclosure - Composition of Certain Financial Statement Captions - Accounts Payable and Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 100350 - Disclosure - Commitments and Contingencies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100360 - Disclosure - Commitments and Contingencies - Summary of Lease Costs (Details) link:presentationLink link:calculationLink link:definitionLink 100370 - Disclosure - Commitments and Contingencies - Summary of Future Minimum Annual Lease Payments under Operating and Financing Leases (Details) link:presentationLink link:calculationLink link:definitionLink 100380 - Disclosure - License Agreements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100390 - Disclosure - Term Loan Obligations - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100400 - Disclosure - Term Loan Obligations - Term Loan Outstanding (Details) link:presentationLink link:calculationLink link:definitionLink 100410 - Disclosure - Term Loan Obligations - Future Payments under Obligation (Details) link:presentationLink link:calculationLink link:definitionLink 100420 - Disclosure - Term Loan Obligations - Face Value to Book Value Reconciliation (Details) link:presentationLink link:calculationLink link:definitionLink 100430 - Disclosure - Grant Revenue - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100440 - Disclosure - Income Taxes - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100450 - Disclosure - Commitments and Contingencies - Summary of Future Minimum Annual Lease Payments under Operating and Financing Leases (Details) 2 link:presentationLink link:calculationLink link:definitionLink 100460 - Disclosure - Income Taxes - Reconciliation of Total Income Tax Provision (Details) link:presentationLink link:calculationLink link:definitionLink 100470 - Disclosure - Income Taxes - Deferred Tax Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 100480 - Disclosure - Income Taxes - Unrecognized Tax Benefits Activity (Details) link:presentationLink link:calculationLink link:definitionLink 100490 - Disclosure - Employee Benefit Plan - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100500 - Disclosure - Stockholders' Equity - Preferred Stock (Details) link:presentationLink link:calculationLink link:definitionLink 100510 - Disclosure - Stockholders' Equity - Warrants (Details) link:presentationLink link:calculationLink link:definitionLink 100520 - Disclosure - Term Loan Obligations - Face Value to Book Value Reconciliation (Details) 2 link:presentationLink link:calculationLink link:definitionLink 100530 - Disclosure - Stockholders' Equity - Common stock (Details) link:presentationLink link:calculationLink link:definitionLink 100540 - Disclosure - Share-based Compensation - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100550 - Disclosure - Share-based Compensation - Stock Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 100560 - Disclosure - Share-based Compensation - Weighted-average Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 100570 - Disclosure - Share-based Compensation - Summary of Share-Based Compensation Recognized (Details) link:presentationLink link:calculationLink link:definitionLink 100580 - Disclosure - Subsequent Events - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink