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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PeriodForRegainCompliance_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Period for regain compliance.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PeriodForRegainCompliance_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Period For Regain Compliance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PeriodForRegainCompliance_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Period for regain compliance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_BusinessCombinationAcquisitionRelatedCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Costs of acquisitions</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from sale of property and equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds from Sale of Property, Plant, and Equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Proceeds from Sale of Property, Plant, and Equipment, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_May2024PrivatePlacementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">May 2024 Private Placement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_May2024PrivatePlacementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">May 2024 Private Placement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_May2024PrivatePlacementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">May 2024 private placement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ProceedsFromIssuanceOfNotesPayableAndWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds from Issuance of Notes Payable and Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ProceedsFromIssuanceOfNotesPayableAndWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Proceeds from issuance of notes payable and warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ProceedsFromIssuanceOfNotesPayableAndWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Issuance of notes payable and warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityIncorporationStateCountryCode_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Incorporation State Country Code</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityIncorporationStateCountryCode_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Incorporation, State or Country Code</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FacilityAndOtherOverheadExpensesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Facility And Other Overhead Expenses [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FacilityAndOtherOverheadExpensesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Facility And Other Overhead Expenses [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockSharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock Shares Issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockSharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Preferred stock, shares issued (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Beginning balance as of January 1, 2025</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Ending balance as of June 30, 2025</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash Flow Noncash Investing And Financing Activities Disclosure [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Supplemental schedule of non-cash investing and financing activities:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NewCapitalSubscriptionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">New Capital Subscriptions [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NewCapitalSubscriptionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">New Capital Subscriptions.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PlanNameAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Plan Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PlanNameAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Plan Name [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCurrentReportingStatus_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Current Reporting Status</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCurrentReportingStatus_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Current Reporting Status</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromWarrantExercises_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds from Warrant Exercises</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromWarrantExercises_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from exercise of Series B Warrants from May 2024 PIPE</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingExpensesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Expenses [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingExpensesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating expenses:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueInputsLevel2Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Inputs, Level 2 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueInputsLevel2Member_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Level 2 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Rollforward</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted Average Exercise Price [Roll Forward]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Commitments And Contingencies Disclosure [Text Block]</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesAuthorized_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock Shares Authorized</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesAuthorized_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock, shares authorized (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NetOfOfferingCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net of offering costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NetOfOfferingCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Net Of Offering Costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NetOfOfferingCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Net of offering costs.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_ProductOrServiceAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Product and Service [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockVotingRights_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Preferred stock, voting rights</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockVotingRights_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock, Voting Rights</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value by Liability Class [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentFiscalPeriodFocus_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Fiscal Period Focus</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentFiscalPeriodFocus_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Fiscal Period Focus</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentInterestRateStatedPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest rate</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentInterestRateStatedPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Maximum interest rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RevenueFromContractWithCustomerAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Revenue from Contract with Customer [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityShellCompany_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Shell Company</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityShellCompany_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Shell Company</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ContractualObligation_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Contractual Obligation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ContractualObligation_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Contractual obligation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ContractualObligation_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Contractual Obligation, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantIssuanceExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrant issuance expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantIssuanceExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Warrant issuance expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityIssues_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Issuances</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityIssues_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Issuance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash And Cash Equivalents At Carrying Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Cash and Cash Equivalents, at Carrying Value, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrant Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Warrant liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrant liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series B Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Series B warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research And Development Arrangement Contract To Perform For Others By Type [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Research and Development Arrangement, Contract to Perform for Others, Type</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock Shares Issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock, shares issued (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Statement [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClosingStockPriceNotBelowZeroPointFiveZeroMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Closing Stock Price Not Below Zero Point Five Zero [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClosingStockPriceNotBelowZeroPointFiveZeroMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Closing Stock Price Not Below Zero Point Five Zero.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClosingStockPriceNotBelowZeroPointFiveZeroMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Closing Stock Price Not Below $0.50 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Statement [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockValueAcquiredCostMethod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Purchase of treasury stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockValueAcquiredCostMethod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Treasury Stock, Value, Acquired, Cost Method</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockValueAcquiredCostMethod_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Purchase of treasury stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RevenueFromContractWithCustomerPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Grant Revenue Recognition</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RevenueFromContractWithCustomerPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Revenue from Contract with Customer [Policy Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrant [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Outstanding Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityFilerCategory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Filer Category</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityFilerCategory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Filer Category</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LiabilitiesAndStockholdersEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liabilities And Stockholders Equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LiabilitiesAndStockholdersEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total liabilities and stockholders' equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercisable at June 30, 2025 (in dollars per share)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashAndCashEquivalentsFairValueDisclosure_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashAndCashEquivalentsFairValueDisclosure_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash and Cash Equivalents, Fair Value Disclosure</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_CashPaidDuringPeriodForAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cash paid during period for:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_CashPaidDuringPeriodForAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash Paid During Period For [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_CashPaidDuringPeriodForAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash paid during period for:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_CongressionallyDirectedMedicalResearchProgramsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Congressionally Directed Medical Research Programs [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_CongressionallyDirectedMedicalResearchProgramsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Congressionally directed medical research programs.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantLiabilityNoncurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrant liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantLiabilityNoncurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrant Liability Noncurrent</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantLiabilityNoncurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Warrant liability noncurrent.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantLiabilityNoncurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Carrying value of warrants exchanged</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ChangeInFairValueOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Change In Fair Value Of Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ChangeInFairValueOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Change in fair value of warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ChangeInFairValueOfWarrants_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Change in fair value of warrant liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsequent Event [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_TwoThousandEighteenRightsOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Two thousand eighteen rights offering.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_TwoThousandEighteenRightsOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Two Thousand Eighteen Rights Offering [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_TwoThousandEighteenRightsOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2018 Rights Offering [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Goodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Goodwill</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Goodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Goodwill</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Goodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Goodwill, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Goodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Goodwill, Beginning Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Goodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Goodwill, Ending Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_InvestmentIncomeInterest_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Investment Income Interest</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_InvestmentIncomeInterest_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockCommonValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Treasury Stock, Common, Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockCommonValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Treasury stock (at cost, 258,425 shares as of March 31, 2025 and December 31, 2024, respectively</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockCommonValue_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Treasury stock (at cost), 258,425 shares as of June 30, 2025 and December 31, 2024, respectively</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsToAcquireIntangibleAssets_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Purchase of intangible assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsToAcquireIntangibleAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Payments to Acquire Intangible Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PreferredStockDividendRatePercentageEliminatedDate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Preferred stock dividend rate percentage eliminated date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PreferredStockDividendRatePercentageEliminatedDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock Dividend Rate Percentage Eliminated Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PreferredStockDividendRatePercentageEliminatedDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series A 3.6% Convertible preferred stock eliminated date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationForfeited_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Shares Issued, Shares, Share-Based Payment Arrangement, Forfeited</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationForfeited_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cancellation of common stock (in Shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationForfeited_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Cancellation of common stock (in Shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_InitialSubscriptionMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Initial Subscription [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_InitialSubscriptionMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Initial Subscription.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RightsRelatedToDistributionOfAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Rights related to distribution of assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RightsRelatedToDistributionOfAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Rights Related To Distribution Of Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RightsRelatedToDistributionOfAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Rights related to distribution of assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SPEAWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">SPEA Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SPEAWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">SPEA Warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfGrantProceedsWithInterestNotExceedAnnually_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of grant proceeds with interest not exceed annually.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfGrantProceedsWithInterestNotExceedAnnually_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Of Grant Proceeds With Interest Not Exceed Annually</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfGrantProceedsWithInterestNotExceedAnnually_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of grant proceeds with interest not exceed annually</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_StockIssuedDuringPeriodValueReclassificationOfWarrantsToEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stock Issued During Period, Value, Reclassification of warrants to equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_StockIssuedDuringPeriodValueReclassificationOfWarrantsToEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Stock issued during period, value, reclassification of warrants to equity.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_StockIssuedDuringPeriodValueReclassificationOfWarrantsToEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Reclassification of 2025 Series B warrant liability to equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesAWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series A Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesAWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Series A Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExchangeOfWarrantsForNotesPayable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Exchange Of Warrants For Notes Payable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExchangeOfWarrantsForNotesPayable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Exchange of warrants for notes payable.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExchangeOfWarrantsForNotesPayable_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Exchange of warrants for notes payable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock shares to be issued (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Granted (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DisaggregationOfRevenueTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disaggregation of Revenue [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MarchTwoThousandTwentyFiveSeriesBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">March Two Thousand Twenty Five Series B Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MarchTwoThousandTwentyFiveSeriesBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">March Two Thousand Twenty Five Series B Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MarchTwoThousandTwentyFiveSeriesBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">March 2025 Series B Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Earnings Per Share Basic</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net loss per share, basic</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Net income (loss) per share of common stock - basic</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AvailableForSaleSecuritiesPurchasedOptionsPricePolicy_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Debt Securities, Available-for-Sale, Premium on Purchased Options [Policy Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AvailableForSaleSecuritiesPurchasedOptionsPricePolicy_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Available-for-Sale Securities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RepaymentsOfLongTermDebt_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Principal payments of term loan obligation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RepaymentsOfLongTermDebt_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Repayments Of Long Term Debt</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RepaymentsOfLongTermDebt_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Repayments of Long-Term Debt, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsForRepurchaseOfEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Payments for Repurchase of Equity, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsForRepurchaseOfEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Payments for Repurchase of Equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsForRepurchaseOfEquity_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Purchase of treasury stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Balance as of December 31, 2024 (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Balance as of June 30, 2025 (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GainLossOnDispositionOfAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loss on disposal of property and equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GainLossOnDispositionOfAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Gain (Loss) on Disposition of Property Plant Equipment, Excluding Oil and Gas Property and Timber Property</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GainLossOnDispositionOfAssets_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Gain on sale of assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LiabilitiesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liabilities Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LiabilitiesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MaximumObligationUnderSingleRegularPurchase_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Maximum Obligation Under Single Regular Purchase</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MaximumObligationUnderSingleRegularPurchase_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Maximum obligation under single regular purchase.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MaximumObligationUnderSingleRegularPurchase_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maximum obligation under single regular purchase</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantsPolicyPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrants Policy [Policy Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantsPolicyPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Warrants Policy.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantsPolicyPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Adjustments to reconcile net loss to net cash used in operating activities:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule of Change in Fair Value of Liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityReclassifiedToEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Reclassified To Equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityReclassifiedToEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value measurement with unobservable inputs reconciliation recurring basis liability reclassified to equity.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityReclassifiedToEquity_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Reclassified to equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExerciseOfPreFundedWarrantsShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise of pre-funded warrants (in Shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExerciseOfPreFundedWarrantsShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Exercise Of Pre-funded Warrants Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExerciseOfPreFundedWarrantsShares_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Exercise of pre-funded warrants shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_LicenseAgreementAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">License agreement abstract.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_LicenseAgreementAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">License Agreement [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfLiquidatedDamagesObligatedToPay_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of liquidated damages obligated to pay</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfLiquidatedDamagesObligatedToPay_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of liquidated damages obligated to pay</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stockholders Equity [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stockholders' equity (deficit):</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SupportLetterParticipationRightsPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Support Letter Participation Rights Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SupportLetterParticipationRightsPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Support letter participation rights period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SupportLetterParticipationRightsPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Support letter participation rights period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntitySmallBusiness_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Small Business</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntitySmallBusiness_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Small Business</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesAConvertiblePreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Series A convertible preferred stock.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesAConvertiblePreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series A Convertible Preferred Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesAConvertiblePreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series A Convertible Preferred Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Accumulated deficit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Retained Earnings Accumulated Deficit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accumulated deficit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Retained Earnings (Accumulated Deficit), Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IssuanceOfCommonStockPrefundedWarrantsAndWarrantsForDebtRepayment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Issuance Of Common Stock, Prefunded Warrants And Warrants For Debt Repayment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IssuanceOfCommonStockPrefundedWarrantsAndWarrantsForDebtRepayment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Issuance of common stock, prefunded warrants and warrants for debt repayment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IssuanceOfCommonStockPrefundedWarrantsAndWarrantsForDebtRepayment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Issuance of common stock, pre-funded warrants and warrants for debt repayment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Preferred Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Convertible Preferred Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GrantsReceivableCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Grants Receivable, Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GrantsReceivableCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Grant receivable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClosingStockPriceNotBelowZeroPointSevenFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Closing Stock Price Not Below $0.75 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClosingStockPriceNotBelowZeroPointSevenFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Closing Stock Price Not Below Zero Point Seven Five [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClosingStockPriceNotBelowZeroPointSevenFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Closing Stock Price Not Below Zero Point Seven Five.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Cancelled/forfeited (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WarrantsAndRightsOutstandingMeasurementInput_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrants and Rights Outstanding, Measurement Input</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WarrantsAndRightsOutstandingMeasurementInput_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrant liability, Measurement input</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Compensation Related Costs Share Based Payments [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock-based Compensation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsToAcquireShortTermInvestments_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Purchase of short-term investments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsToAcquireShortTermInvestments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Payments to Acquire Short-Term Investments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Organization Consolidation And Presentation Of Financial Statements [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_UnconditionalPurchaseObligationCategoryOfGoodsOrServicesAcquiredDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Unconditional Purchase Obligation, Category of Goods or Services Acquired [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PotentialFinancingPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Potential financing percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PotentialFinancingPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Potential Financing Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PotentialFinancingPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Potential financing percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_AmendmentFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Amendment Flag</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_AmendmentFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amendment Flag</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_ProductsAndServicesDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Product and Service [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RegainComplianceExpiryDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Regain Compliance Expiry Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RegainComplianceExpiryDate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Regain compliance expiry date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RegainComplianceExpiryDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Regain compliance expiry date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageAgreedToRepayPurchasersHoldingSecurities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Agreed to Repay Purchasers Holding Securities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageAgreedToRepayPurchasersHoldingSecurities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage agreed to repay purchasers holding securities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageAgreedToRepayPurchasersHoldingSecurities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage agreed to repay purchasers holding securities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of shares callable by warrants (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Number of securities called by warrant or right</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LiabilitiesAndStockholdersEquityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liabilities And Stockholders Equity [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LiabilitiesAndStockholdersEquityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Liabilities and Stockholders' Equity (Deficit)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressPostalZipCode_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address Postal Zip Code</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressPostalZipCode_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, Postal Zip Code</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Net Cash Provided By Used In Operating Activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net cash used in operating activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net cash used in operating activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInOperatingLeaseLiability_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Change in operating lease liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInOperatingLeaseLiability_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (Decrease) in Operating Lease Liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accounting Standards Update and Change in Accounting Principle [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MaximumValueOfSharesToBeIssuedUnderAgreement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Maximum Value of Shares to be Issued Under Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MaximumValueOfSharesToBeIssuedUnderAgreement_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Maximum value of shares to be issued under agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MaximumValueOfSharesToBeIssuedUnderAgreement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maximum value of shares to be issued under agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Granted (in dollars per share)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research And Development Arrangement Contract To Perform For Others Type [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Research and Development Arrangement, Contract to Perform for Others, Type</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressAddressLine1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address Address Line1</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressAddressLine1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, Address Line One</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ChangeInAccountingPrincipleAccountingStandardsUpdateImmaterialEffect_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Change in accounting principle, accounting standards update, immaterial effect</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ChangeInAccountingPrincipleAccountingStandardsUpdateImmaterialEffect_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Hierarchy and NAV [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Earnings Per Share [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SupplementalCashFlowInformationAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Supplemental Cash Flow Information [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SupplementalCashFlowInformationAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Supplemental disclosure of cash flows information:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfProceedsToRepayPurchasersFromCapitalRaised_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of Proceeds to Repay Purchasers from Capital Raised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfProceedsToRepayPurchasersFromCapitalRaised_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of proceeds to repay purchasers from capital raised.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfProceedsToRepayPurchasersFromCapitalRaised_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of proceeds to repay purchasers from capital raised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FebruaryTwoThousandTwentyFiveSecuritiesPurchaseAndExchangeAgreementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">February Two Thousand Twenty Five Securities Purchase and Exchange Agreements [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FebruaryTwoThousandTwentyFiveSecuritiesPurchaseAndExchangeAgreementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">February two thousand twenty five securities purchase and exchange agreements.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FebruaryTwoThousandTwentyFiveSecuritiesPurchaseAndExchangeAgreementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">February 2025 SPEA Agreements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_StockBasedCompensation2015EquityIncentivePlan1Member_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Stock based compensation 2015 equity incentive plan 1 member.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_StockBasedCompensation2015EquityIncentivePlan1Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stock Based Compensation2015 Equity Incentive Plan1 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_StockBasedCompensation2015EquityIncentivePlan1Member_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2015 Plan [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_InvestmentTypeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Investment Type [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_InvestmentTypeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investment Type</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MarchTwoThousandTwentyFiveSeriesAAndBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">March 2025 Series A and B Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MarchTwoThousandTwentyFiveSeriesAAndBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">March Two Thousand Twenty Five Series A and B Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MarchTwoThousandTwentyFiveSeriesAAndBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">March two thousand twenty five series A and B warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseRightOfUseAsset_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Lease Right Of Use Asset</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseRightOfUseAsset_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating lease right-use-of assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RedemptionOfShortTermInvestments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Redemption of short-term investments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RedemptionOfShortTermInvestments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Redemption of Short-Term Investments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RedemptionOfShortTermInvestments_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Redemption of Short-Term Investments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PershingCreditFacilityMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Pershing Credit Facility [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PershingCreditFacilityMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Pershing Credit Facility [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PershingCreditFacilityMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Pershing Credit Facility.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_CharlottesvilleMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Charlottesville</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_CharlottesvilleMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Charlottesville [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_CharlottesvilleMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Charlottesville [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class of Warrant or Right</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClassOfWarrantOrRightExpirationPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expiration period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClassOfWarrantOrRightExpirationPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class of Warrant or Right Expiration Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClassOfWarrantOrRightExpirationPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class of warrant or right expiration period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentType_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Type</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentType_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Type</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExchangeNotesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Exchange Notes [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExchangeNotesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Exchange notes.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExchangeNotesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exchange Notes</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TypeOfArrangementAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Type Of Arrangement [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TypeOfArrangementAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Collaborative Arrangement and Arrangement Other than Collaborative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Arrangements And Nonarrangement Transactions [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Collaborative Arrangement and Arrangement Other than Collaborative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCentralIndexKey_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Central Index Key</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCentralIndexKey_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Central Index Key</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LineOfCreditFacilityTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Line of Credit Facility [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetAcquisitionTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Asset Acquisition [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net increase (decrease) in cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventTypeDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsequent Event Type [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAdjustmentOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value of warrant liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAdjustmentOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Change in fair value of warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAdjustmentOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Adjustment Of Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Dilutive common shares excluded from the calculations of diluted loss per share (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShortTermDebtTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Short-Term Debt [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShortTermDebtTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Line of Credit Facility</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_LicenseAgreementDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of accounting policy for license agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_LicenseAgreementDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">License Agreement Disclosure [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_LicenseAgreementDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">License Agreements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockParOrStatedValuePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock Par Or Stated Value Per Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockParOrStatedValuePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock, par value (in dollars per share)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromIssuanceOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds from Issuance of Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromIssuanceOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from issuance of warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PrefundedWarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Prefunded Warrant [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PrefundedWarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Prefunded Warrant.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Reduction in the carrying amount of operating lease right-of-use assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Lease, Right-of-Use Asset, Periodic Reduction</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_OptionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Options.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_OptionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Options [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_OptionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Outstanding Stock Options [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Balance as of June 30, 2025</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Debt Securities, Available-for-Sale, Amortized Cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Debt Securities, available-for-sale, amortized cost and fair value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Amortized Cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Amortized Cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AggregatePurchasePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Aggregate Purchase Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AggregatePurchasePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Aggregate purchase price.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AggregatePurchasePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Aggregate purchase price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PotentialCashPayment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Potential Cash Payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PotentialCashPayment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Potential cash payment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PotentialCashPayment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Potential cash payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherPrepaidExpenseCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Prepaid Expense, Current</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ProfessionalExpensesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Professional Expenses [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ProfessionalExpensesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Professional expenses.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementInputsDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Measurement Inputs Disclosure [Text Block]</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MarketableSecurities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Marketable Securities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MarketableSecurities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Marketable Securities, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MarketableSecurities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Collateralized marketable securities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FinancingExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financing expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FinancingExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financing Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FinancingExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Financing expense.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ProceedsFromGrantsReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Grant payment received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ProceedsFromGrantsReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds from Grants Received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ProceedsFromGrantsReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Proceeds from grants received.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SeriesFPreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series F Preferred Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SeriesFPreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series F Preferred Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CurrentFiscalYearEndDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current Fiscal Year End Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CurrentFiscalYearEndDate_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Current Fiscal Year End Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ModificationPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Modification Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ModificationPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Modification period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ModificationPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Modification period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentQuarterlyReport_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Quarterly Report</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentQuarterlyReport_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Quarterly Report</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DistributionTypeDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Distribution Type [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_LincolnParkCapitalFundLLCMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Lincoln park capital fund, LLC.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_LincolnParkCapitalFundLLCMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lincoln Park Capital Fund L L C [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_LincolnParkCapitalFundLLCMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Lincoln Park Capital Fund, LLC [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressStateOrProvince_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address State Or Province</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressStateOrProvince_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, State or Province</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AdditionalAcceleratedPurchasePricePerShareThresholdPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additional Accelerated Purchase Price Per share Threshold Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AdditionalAcceleratedPurchasePricePerShareThresholdPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Additional accelerated purchase price per share threshold percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AdditionalAcceleratedPurchasePricePerShareThresholdPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additional accelerated purchase price per share threshold percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stock Issued During Period Value Conversion Of Convertible Securities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Conversion of Series B Convertible Preferred Stock into common stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ConsiderationPaidToPreferredStockHolders_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Consideration paid to preferred stock holders</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ConsiderationPaidToPreferredStockHolders_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Consideration Paid To Preferred Stock Holders</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ConsiderationPaidToPreferredStockHolders_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Consideration paid to preferred stock holders.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_UseOfEstimatesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Use of Estimates [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_UseOfEstimatesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Use Of Estimates [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetAcquisitionDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Asset Acquisition [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock Shares Outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Preferred stock, shares outstanding (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Preferred Stock, Shares Outstanding, Beginning Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Preferred Stock, Shares Outstanding, Ending Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class of Warrant or Right</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IncreaseDecreaseInGrantReceivable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease In Grant Receivable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IncreaseDecreaseInGrantReceivable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase decrease in grant receivable.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IncreaseDecreaseInGrantReceivable_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Grant receivable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsForRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Payments For Royalties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsForRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">License fee payment in cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PeriodExercisableFromTheDateOfIssuance_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Refers to the period exercisable from the date of issuance.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PeriodExercisableFromTheDateOfIssuance_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Period Exercisable From The Date Of Issuance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PeriodExercisableFromTheDateOfIssuance_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Period exercisable from the date of issuance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IssuanceOfCommonStockSharesPrefundedWarrantsAndWarrantsForDebtRepayment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Issuance Of Common Stock Shares, Prefunded Warrants And Warrants For Debt Repayment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IssuanceOfCommonStockSharesPrefundedWarrantsAndWarrantsForDebtRepayment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Issuance of common stock shares, prefunded warrants and warrants for debt repayment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IssuanceOfCommonStockSharesPrefundedWarrantsAndWarrantsForDebtRepayment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Issuance of common stock, pre-funded warrants and warrants for debt repayment (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ConsecutiveBusinessDays_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Consecutive business days.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ConsecutiveBusinessDays_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Consecutive Business Days</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ConsecutiveBusinessDays_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Consecutive business days</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsequent Event [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Subsequent Event [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MayTwoThousandTwentyFourSeriesBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">May 2024 Series B Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MayTwoThousandTwentyFourSeriesBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">May Two Thousand Twenty Four Series B Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MayTwoThousandTwentyFourSeriesBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">May Two Thousand Twenty Four Series B Warrants Member.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ContractEffectiveDate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Contract effective date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ContractEffectiveDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Contract Effective Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ContractEffectiveDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Contract effective date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherAssetsNoncurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Assets Noncurrent</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherAssetsNoncurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Measurement Inputs and Valuation Techniques [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TypeOfRevenueExtensibleList_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Revenue, Product and Service [Extensible Enumeration]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sharebased Compensation Arrangement By Sharebased Payment Award Award Vesting Rights Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock option vesting percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Basis Of Presentation And Significant Accounting Policies [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_BasisOfPresentationAndSignificantAccountingPoliciesTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Basis of Presentation and New Accounting Standards</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MayTwoThousandTwentyFourPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">May 2024 Purchase Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MayTwoThousandTwentyFourPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">May Two Thousand Twenty Four Purchase Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MayTwoThousandTwentyFourPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">May two thousand twenty four purchase agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Vested and expected to vest as of June 30, 2025</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercisable at June 30, 2025</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClosingStockPriceNotBelowZeroPointOneZeroMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Closing Stock Price Not Below Zero Point One Zero [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClosingStockPriceNotBelowZeroPointOneZeroMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Closing Stock Price Not Below Zero Point One Zero.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClosingStockPriceNotBelowZeroPointOneZeroMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Closing Stock Price Not Below $0.10 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_StockIssuedDuringPeriodSharesWarrantsExerciseShares_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Stock issued during period shares warrants exercise(shares).</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_StockIssuedDuringPeriodSharesWarrantsExerciseShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stock Issued During Period Shares Warrants Exercise Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_StockIssuedDuringPeriodSharesWarrantsExerciseShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise of Series B Warrants from May 2024 PIPE (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockCommonShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Treasury stock, shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockCommonShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Treasury Stock, Common, Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockCommonShares_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Balance, Treasury (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockCommonShares_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Balance, Treasury (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash and Cash Equivalents [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareDilutedTwoClassMethodAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Diluted net loss per common share calculation:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareDilutedTwoClassMethodAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Earnings Per Share, Diluted, Two Class Method [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MaximumBeneficialOwnershipPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maximum beneficial ownership percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MaximumBeneficialOwnershipPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Maximum Beneficial Ownership Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MaximumBeneficialOwnershipPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Maximum beneficial ownership percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LesseeOperatingLeaseOptionToExtend_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lessee Operating Lease Option To Extend</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LesseeOperatingLeaseOptionToExtend_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Lessee, operating lease, option to extend</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Preferred stock, $0.001 par value; 5,000,000 shares authorized; 1,952 shares issued and outstanding as of June 30, 2025 and December 31, 2024, respectively</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentMaturityDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Debt Instrument Maturity Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentMaturityDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maturity date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_MinimumMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Minimum [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_MinimumMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Minimum [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FinancialInstrumentAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial Instrument [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FinancialInstrumentAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial Instrument</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsCurrentAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Assets Current [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsCurrentAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current assets:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RecordedUnconditionalPurchaseObligationTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Recorded Unconditional Purchase Obligation [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RecordedUnconditionalPurchaseObligationTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Recorded Unconditional Purchase Obligation [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_LiquidityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Liquidity Abstract</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_LiquidityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liquidity [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueInputsLevel3Member_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Level 3 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueInputsLevel3Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Inputs, Level 3 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsCancelledOrForfeitedInPeriodTotalIntrinsicValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cancelled/forfeited</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsCancelledOrForfeitedInPeriodTotalIntrinsicValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Options Cancelled or Forfeited In Period Total Intrinsic Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsCancelledOrForfeitedInPeriodTotalIntrinsicValue_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Share based compensation arrangement by share based payment award options cancelled or forfeited in period total intrinsic value.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_InitialCommitmentShares_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Initial commitment shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_InitialCommitmentShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Initial Commitment Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_InitialCommitmentShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Initial commitment shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityModificationAndExtinguishment_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Modification and extinguishment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityModificationAndExtinguishment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Modification and Extinguishment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityModificationAndExtinguishment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value measurement with unobservable inputs reconciliation recurring basis liability modification and extinguishment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SegmentReportingAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Segment Reporting [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAssetsMeasuredOnRecurringBasisTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Financial Assets Measured at Fair Value on Recurring Basis</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAssetsMeasuredOnRecurringBasisTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Assets Measured on Recurring Basis [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LiabilitiesCurrentAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liabilities Current [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LiabilitiesCurrentAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current liabilities:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Shares Outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Balance (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Balance (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommitmentsAndContingencies_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Commitments And Contingencies</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommitmentsAndContingencies_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commitments and contingencies (Note 7)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_OfferingCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Offering Costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_OfferingCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Offering costs.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_OfferingCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Offering expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MarchTwoThousandTwentyFivePrivatePlacementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">March 2025 Private Placement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MarchTwoThousandTwentyFivePrivatePlacementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">March Two Thousand Twenty Five Private Placement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MarchTwoThousandTwentyFivePrivatePlacementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">March Two Thousand Twenty Five Private Placement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MarchTwoThousandTwentyFivePrivatePlacementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">March 2025 Private Placement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DeferredIncomeCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred grant liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DeferredIncomeCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Income, Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Debt Instrument Basis Spread On Variable Rate1</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Basis variable rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Basis variable rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquityReverseStockSplit_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stockholders' Equity, Reverse Stock Split</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquityReverseStockSplit_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Reverse stock split</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockDividendRatePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock Dividend Rate Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockDividendRatePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Convertible preferred stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_ScenarioForecastMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Forecast [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_ScenarioForecastMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Forecast [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AdditionalCommitmentFee_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additional Commitment Fee</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AdditionalCommitmentFee_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Additional commitment fee.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AdditionalCommitmentFee_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additional commitment fee paid in cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ContractTerminationDate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Contract termination date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ContractTerminationDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Contract Termination Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ContractTerminationDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Contract termination date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RemeasurementOfWarrantLiability_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Remeasurement of Warrant Liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RemeasurementOfWarrantLiability_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Remeasurement of warrant liability.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RemeasurementOfWarrantLiability_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Remeasurement of warrant liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LineOfCreditFacilityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Line of Credit Facility [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted Average Number Of Shares Outstanding Basic</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Weighted average common shares outstanding - basic</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted average number of shares of common stock outstanding - basic</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_StatementScenarioAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Scenario [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareBasicTwoClassMethodAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Earnings Per Share, Basic, Two Class Method [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareBasicTwoClassMethodAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Basic net loss per common share calculation:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Exercisable at June 30, 2025</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SegmentReportingExpenseInformationUsedByCodmDescription_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Segment Reporting, Expense Information Used by CODM, Description</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SegmentReportingExpenseInformationUsedByCodmDescription_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Segment Reporting, Expense Information Used by CODM, Description</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncomeLossFromContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Income (Loss) from Continuing Operations, Net of Tax, Attributable to Parent, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncomeLossFromContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Income (Loss) from Continuing Operations, Net of Tax, Attributable to Parent</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncomeLossFromContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net income from continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_GrantFundingTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Grant funding term.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_GrantFundingTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Grant Funding Term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_GrantFundingTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Grant funding term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromIssuanceOfPrivatePlacement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from private placement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromIssuanceOfPrivatePlacement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds from Issuance of Private Placement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsequent Events [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Subsequent Events</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock-based compensation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">APIC, Share-Based Payment Arrangement, Increase for Cost Recognition, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesDiluted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Undistributed Earnings (Loss) Allocated to Participating Securities, Diluted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesDiluted_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Income attributable to 2025 Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stockholders' deficit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stockholders Equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total stockholders' equity (deficit)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Stockholders' equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockParOrStatedValuePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock Par Or Stated Value Per Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockParOrStatedValuePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Preferred stock, par value (in dollars per share)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_BasisOfAccountingPolicyPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Basis Of Accounting Policy Policy [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_BasisOfAccountingPolicyPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Basis of Presentation and New Accounting Standards</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementOfStockholdersEquityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement Of Stockholders Equity [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_UseOfEstimates_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Use of Estimates</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_UseOfEstimates_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Use of Estimates, Policy [Policy Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockCommonMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Treasury Stock, Common [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockCommonMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Treasury Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressAddressLine2_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address Address Line2</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressAddressLine2_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, Address Line Two</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_LetterAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Letter Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_LetterAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Letter Agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_LetterAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Letter Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Roll Forward</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Options [Roll Forward]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherAssetsCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Assets Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherAssetsCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherAssetsCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total other current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MaximumBeneficialOwnershipPercentageByElectionOfHolder_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Maximum Beneficial Ownership Percentage By Election Of Holder</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MaximumBeneficialOwnershipPercentageByElectionOfHolder_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Maximum beneficial ownership percentage by election of holder.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MaximumBeneficialOwnershipPercentageByElectionOfHolder_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maximum beneficial ownership percentage by election of holder</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SegmentReportingCodmIndividualTitleAndPositionOrGroupOrCommitteeNameExtensibleEnumeration_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PlanNameDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Plan Name [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PlanNameDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Plan Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_InitialCommitmentFee_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Initial commitment fee.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_InitialCommitmentFee_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Initial Commitment Fee</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_InitialCommitmentFee_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Initial commitment fee paid in cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_InitialCommitmentFee_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Initial commitment fee</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Settlements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Settlement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Excess of fair value of instruments issued over cash received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CreditFacilityAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Credit Facility [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Exercisable Weighted Average Exercise Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Vested and expected to vest at June 30, 2025 (in dollars per share)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesFConvertiblePreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series F Convertible Preferred Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesFConvertiblePreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Series F Convertible Preferred Stock.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class of warrant outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Number of base warrant shares at issuance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockValue_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Treasury Stock, Value, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Treasury Stock, Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Treasury stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_StockIssuedDuringPeriodSharesExerciseOfSeriesBWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise of March 2025 Series B Warrants (in Shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_StockIssuedDuringPeriodSharesExerciseOfSeriesBWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stock Issued During Period, Shares, Exercise of Series B Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_StockIssuedDuringPeriodSharesExerciseOfSeriesBWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Stock issued during period, shares, exercise of Series B warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Related Party Transactions By Related Party [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Related Party</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetAcquisitionTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Asset Acquisition [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetAcquisitionTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Biocept Asset Acquisitions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class of Warrant or Right [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AccountingStandardsUpdateExtensibleList_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accounting Standards Update [Extensible Enumeration]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressCityOrTown_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address City Or Town</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressCityOrTown_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, City or Town</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule of Earnings Per Share, Diluted, by Common Class, Including Two Class Method [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule of Computation of Diluted Net Loss per Share of Common Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockRepurchasedDuringPeriodShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stock Repurchased During Period, Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockRepurchasedDuringPeriodShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of stock repurchased</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AcceleratedPurchasePricePerShareThresholdPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accelerated purchase price per share threshold percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AcceleratedPurchasePricePerShareThresholdPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accelerated Purchase Price Per share Threshold Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AcceleratedPurchasePricePerShareThresholdPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Accelerated purchase price per share threshold percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_SecurityExchangeName_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Security Exchange Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_SecurityExchangeName_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Security Exchange Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CreditFacilityDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Credit Facility [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClinicalDevelopmentAndLicensingExpensesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Clinical Development and Licensing Expenses [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClinicalDevelopmentAndLicensingExpensesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Clinical Development and Licensing Expenses.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Share based compensation arrangement by share based payment award options aggregate intrinsic value.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Aggregated Intrinsic Value [Roll Forward]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement by Share Based Payment Award Options Aggregate Intrinsic Value [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Number</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Vested and expected to vest at June 30, 2025 (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MeasurementInputTypeDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Measurement Input Type [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NanoTxLicensesAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Nano Tx license agreement Member</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NanoTxLicensesAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Nano Tx Licenses Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NanoTxLicensesAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Nano Tx Licenses Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ConvertibleNotesTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Convertible Notes Term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ConvertibleNotesTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Convertible notes term.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquityNoteAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stockholders Equity Note [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_DisclosureOfLiquidityAndGoingConcernTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of liquidity and going concern text block</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_DisclosureOfLiquidityAndGoingConcernTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Liquidity and Going Concern</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_DisclosureOfLiquidityAndGoingConcernTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Liquidity And Going Concern Text Block</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_InterestPaidNet_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Interest Paid Net</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_InterestPaidNet_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_RangeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Statistical Measurement [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_RangeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Range [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_RangeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Statistical Measurement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrant exercise price (in dollars per share)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Assets Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExtinguishmentOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Extinguishment of Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExtinguishmentOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Extinguishment of Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExtinguishmentOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Extinguishment of Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentPeriodEndDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Period End Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentPeriodEndDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Period End Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherIncomeAndExpensesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Income And Expenses [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherIncomeAndExpensesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other income (expense):</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementsFairValueHierarchyDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Hierarchy and NAV [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AdjustmentsToAdditionalPaidInCapitalModificationOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustments To Additional Paid In Capital Modification Of Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AdjustmentsToAdditionalPaidInCapitalModificationOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Adjustments to additional paid in capital, modification of warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AdjustmentsToAdditionalPaidInCapitalModificationOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Modification of warrants (Note 12)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ResearchAndDevelopmentAwardInPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research And Development Award In Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ResearchAndDevelopmentAwardInPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Research and development award in period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ResearchAndDevelopmentAwardInPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Research and development award in period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercisable at June 30, 2025 (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LineOfCreditFacilityCommitmentFeePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Line of Credit Facility, Commitment Fee Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LineOfCreditFacilityCommitmentFeePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Applicable fees</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfNonDilutiveMonetaryAwardsRequiredToPay_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of non-dilutive monetary awards required to pay</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfNonDilutiveMonetaryAwardsRequiredToPay_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of Non-dilutive Monetary awards Required to Pay</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfNonDilutiveMonetaryAwardsRequiredToPay_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of non-dilutive monetary awards required to pay.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesCConvertiblePreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Series C convertible preferred stock.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesCConvertiblePreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series C Convertible Preferred Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesCConvertiblePreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series C Convertible Preferred Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FirstPaymentReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/label">First Payment Received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FirstPaymentReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">First Payment Received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FirstPaymentReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">First payment received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementOfFinancialPositionAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement Of Financial Position [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PreClinicalResearchStudyObligationsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Contractual obligation to provide funding of research and development costs over periods that initially exceed one year or the normal operating cycle, if longer.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PreClinicalResearchStudyObligationsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Pre Clinical Research Study Obligations [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PreClinicalResearchStudyObligationsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Pre-clinical Research Study Obligations [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementClassOfStockAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement Class Of Stock [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementClassOfStockAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class of Stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClassOfWarrantOrRightWarrantsExerciseRatio_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Warrants Exercise Ratio</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClassOfWarrantOrRightWarrantsExerciseRatio_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class Of Warrant Or Right Warrants Exercise Ratio.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClassOfWarrantOrRightWarrantsExerciseRatio_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrants exercise ratio</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Liabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Liabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LesseeOperatingLeaseDiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating lease discount rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LesseeOperatingLeaseDiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lessee, Operating Lease, Discount Rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MinimumStockholdersEquityRequirementDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Minimum Stockholders Equity Requirement Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MinimumStockholdersEquityRequirementDate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Minimum stockholder's equity requirement date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MinimumStockholdersEquityRequirementDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Minimum stockholder's equity requirement date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial Instruments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AdditionalSubscriptionMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additional Subscription [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AdditionalSubscriptionMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Additional Subscription.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesBConvertiblePreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Series B convertible preferred stock.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesBConvertiblePreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series B Convertible Preferred Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesBConvertiblePreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series B Convertible Preferred Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PrepaidExpenseAndOtherAssetsCurrentAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Prepaid Expense and Other Assets, Current [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted Average Number Of Diluted Shares Outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Weighted average common shares outstanding - diluted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted average number of shares of common stock outstanding - diluted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityFileNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity File Number</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityFileNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity File Number</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CoverAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cover [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ChangeInFairValueOfDerivativeInstruments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Change in fair value of derivative instruments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ChangeInFairValueOfDerivativeInstruments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Change In Fair Value Of Derivative Instruments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ChangeInFairValueOfDerivativeInstruments_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Change in fair value of derivative instruments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ChangeInFairValueOfDerivativeInstruments_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Change in fair value of derivative instruments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfAggregateAmountOfProceedsAwardedUnderCpritGrant_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of aggregate amount of proceeds awarded under CPRIT grant.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfAggregateAmountOfProceedsAwardedUnderCpritGrant_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Of Aggregate Amount Of Proceeds Awarded Under CPRIT Grant</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfAggregateAmountOfProceedsAwardedUnderCpritGrant_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of aggregate amount of proceeds awarded under CPRIT grant</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfVotesPerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Votes Per Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfVotesPerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of votes per share.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExchangeOfWarrantForNotesPayable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Exchange of Warrant for Notes Payable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExchangeOfWarrantForNotesPayable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Exchange of warrant for notes payable.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExchangeOfWarrantForNotesPayable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exchange of warrants for notes payable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MeasurementInputTypeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Measurement Input Type [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease In Accounts Payable And Accrued Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accounts payable and accrued expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Increase (Decrease) in Accounts Payable and Accrued Liabilities, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClosingBidPriceForCommonStockHadFallenBelow_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Closing bid price for common stock had fallen.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClosingBidPriceForCommonStockHadFallenBelow_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Closing Bid Price For Common Stock Had Fallen Below</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ClosingBidPriceForCommonStockHadFallenBelow_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Closing bid price for common stock had fallen below</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_InvestmentTypeCategorizationMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Investment Type Categorization [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_InvestmentTypeCategorizationMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Supplemental Balance Sheet Disclosures [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Composition of Certain Financial Statement Captions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_ScenarioUnspecifiedDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Scenario [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_USTreasurySecuritiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">US Treasury Securities [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_USTreasurySecuritiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">U.S. Treasury Securities [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_USTreasurySecuritiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Treasury Bills and Treasury Note[Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DistributionsMadeToMemberOrLimitedPartnerByDistributionTypeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Distribution Type [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NumberOfOperatingSegments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of operating segment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NumberOfOperatingSegments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of Operating Segments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SaleOfStockNameOfTransactionDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sale Of Stock Name Of Transaction [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SaleOfStockNameOfTransactionDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Sale of Stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SegmentReportingDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Segment Information</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SegmentReportingDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Segment Reporting Disclosure [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MaintainMinimumMarketValueOfListedSecurities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maintain minimum market value of listed securities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MaintainMinimumMarketValueOfListedSecurities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Maintain minimum market value of listed securities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MaintainMinimumMarketValueOfListedSecurities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Maintain Minimum Market Value of Listed Securities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GeneralAndAdministrativeExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">General And Administrative Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GeneralAndAdministrativeExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">General and administrative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GeneralAndAdministrativeExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total general and administrative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsequent Event [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_CpritGrantFundingTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">CPRIT grant funding term.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_CpritGrantFundingTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/label">CPRIT Grant Funding Term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_CpritGrantFundingTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">CPRIT grant funding term, description</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfEarningsPerShareDilutedByCommonClassTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Earnings Per Share, Diluted, by Common Class, Including Two-Class Method [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Options Additional Disclosures [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted Average Remaining Contractual Life (years) [Roll Forward]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FinancingPercentageAfterModificationPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financing percentage after modification period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FinancingPercentageAfterModificationPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financing Percentage After Modification Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FinancingPercentageAfterModificationPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Financing percentage after modification period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">New Accounting Pronouncements, Policy [Policy Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Recently Issued Accounting Pronouncements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stock Issued During Period Shares Conversion Of Convertible Securities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Conversion of Series B Convertible Preferred Stock into common stock (share)</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock option vesting period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock Shares Outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock, shares outstanding (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Common Stock, Shares, Outstanding, Beginning Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Common Stock, Shares, Outstanding, Ending Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseLiabilityCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Lease Liability Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseLiabilityCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating lease liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseLiabilityCurrent_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Less: current portion</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ConvertibleNotesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Convertible Notes [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ConvertibleNotesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Convertible notes.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DepreciationDepletionAndAmortization_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Depreciation Depletion And Amortization</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DepreciationDepletionAndAmortization_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Depreciation and amortization</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DepreciationDepletionAndAmortization_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Depreciation, Depletion and Amortization, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentTransitionReport_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Transition Report</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentTransitionReport_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Transition Report</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_UnrecordedUnconditionalPurchaseObligationByCategoryOfItemPurchasedAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Unrecorded Unconditional Purchase Obligation by Category of Item Purchased [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShortTermInvestments_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Short-Term Investments, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShortTermInvestments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Short-Term Investments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShortTermInvestments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total operating expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Research and development expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research And Development Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Research and development</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total research and development</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ConvertiblePreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Convertible Preferred Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ConvertiblePreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Convertible Preferred Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementOfCashFlowsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement Of Cash Flows [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfWarrantsExercised_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of warrants exercised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfWarrantsExercised_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Warrants Exercised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfWarrantsExercised_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of warrants exercised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodValueNewIssues_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stockholders' equity requirement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodValueNewIssues_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Issue and sale of stock, net</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodValueNewIssues_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Issuance of common stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IncreaseDecreaseInDeferredGrantLiability_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred grant liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IncreaseDecreaseInDeferredGrantLiability_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase (decrease) in deferred grant liability.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IncreaseDecreaseInDeferredGrantLiability_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease In Deferred Grant Liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FairValueOfWarrantLiabilityReclassifiedToEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value of warrant liability reclassified to equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FairValueOfWarrantLiabilityReclassifiedToEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value of Warrant Liability Reclassified to Equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FairValueOfWarrantLiabilityReclassifiedToEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair Value of Warrant Liability Reclassified to Equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfSharesIssuableUponExercise_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Shares Issuable Upon Exercise</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfSharesIssuableUponExercise_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of shares issuable upon exercise.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfSharesIssuableUponExercise_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of shares issuable upon exercise</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AmountToBeReceivedAsAwardForResearchAndDevelopment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Amount To Be Received As Award For Research And Development</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AmountToBeReceivedAsAwardForResearchAndDevelopment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount to be received as award for research and development.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AmountToBeReceivedAsAwardForResearchAndDevelopment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amount to be received as award for research and development</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_CompositionOfCertainFinancialStatementCaptionsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Composition of Certain Financial Statement Captions [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_CompositionOfCertainFinancialStatementCaptionsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Composition Of Certain Financial Statement Captions [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FundingNotesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Funding Notes [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FundingNotesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Funding notes.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FundingNotesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Funding Notes</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquityNoteDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stockholders Equity Note Disclosure [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquityNoteDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stockholders' Equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Earnings Per Share [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loss per Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetIncomeLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Net income (loss)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetIncomeLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net income (loss)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantIssuanceCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrant Issuance Costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantIssuanceCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Warrant issuance costs.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantIssuanceCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrant issuance costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantIssuanceCosts_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Warrant issuance costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_WarrantIssuanceCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Warrant issuance expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Balance as of December 31, 2024</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Balance as of June 30, 2025</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PrivatePlacementAndPrefundedWarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Private Placement And Prefunded Warrant [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PrivatePlacementAndPrefundedWarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Private Placement and Prefunded Warrant[Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PrivatePlacementAndPrefundedWarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Private Placement and Prefunded Warrant.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherIntangibleAssetsNet_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Intangible Assets Net</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherIntangibleAssetsNet_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Intangible assets, net</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WarrantsAndRightsOutstandingTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Warrant liability, Remaining term (years)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WarrantsAndRightsOutstandingTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrants And Rights Outstanding Term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WarrantsAndRightsOutstandingTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrants expected term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareBasicLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExerciseOfPreFundedWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise of pre-funded warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExerciseOfPreFundedWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Exercise Of Pre-funded Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExerciseOfPreFundedWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Exercise of pre-funded warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_ExerciseOfPreFundedWarrants_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Exercise of pre-funded warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PotentialLiquidatedDamagesPaymentLiability_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Potential liquidated damages payment liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PotentialLiquidatedDamagesPaymentLiability_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Potential liquidated damages payment liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LineOfCreditFacilityLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Line of Credit Facility [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableAggregateIntrinsicValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableAggregateIntrinsicValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Vested and expected to vest as of March 31, 2025</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Assets [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AmortizationOfFinancingCostsAndDiscounts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Amortization Of Financing Costs And Discounts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AmortizationOfFinancingCostsAndDiscounts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amortization of deferred financing costs and debt discount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AmortizationOfFinancingCostsAndDiscounts_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Amortization of Debt Issuance Costs and Discounts, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_GrantAdvancePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Grant Advance Payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_GrantAdvancePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Grant advance payment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_GrantAdvancePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Grant advance payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentFiscalYearFocus_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Fiscal Year Focus</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentFiscalYearFocus_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Fiscal Year Focus</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentMeasurementInput_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Debt Instrument, Measurement Input</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPeriodIncreaseDecrease_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Period Increase (Decrease)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPeriodIncreaseDecrease_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Period Increase (Decrease), Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPeriodIncreaseDecrease_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Change in fair value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPeriodIncreaseDecrease_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Changes in the fair value of Notes</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IssuanceOfCommonStockPrefundedWarrantsAndWarrantsNetOfOfferingCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Issuance Of Common Stock, Prefunded Warrants And Warrants, Net Of Offering Costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IssuanceOfCommonStockPrefundedWarrantsAndWarrantsNetOfOfferingCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Issuance of common stock, prefunded warrants and warrants, net of offering costs .</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IssuanceOfCommonStockPrefundedWarrantsAndWarrantsNetOfOfferingCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Issuance of common stock, prefunded warrants and warrants, net of offering costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Net Cash Provided By Used In Investing Activities [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash flows used in investing activities:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule of Earnings Per Share, Basic, by Common Class, Including Two Class Method [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule of Computation of Basic Net Loss per Common Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfMaximumCommonSharesCanBeResale_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of maximum common shares can be resale</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfMaximumCommonSharesCanBeResale_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of Maximum Common Shares Can Be Resale</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfMaximumCommonSharesCanBeResale_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of maximum common shares can be resale.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_InterestExpenseNonoperating_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Interest expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_InterestExpenseNonoperating_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Interest Expense, Nonoperating</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_InterestExpenseNonoperating_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Interest Expense, Nonoperating, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accounting Standards Update and Change in Accounting Principle [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DeferredRevenue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Revenue</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DeferredRevenue_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Deferred Revenue, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DeferredRevenue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred grant liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueDisclosuresAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Disclosures [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommitmentsAndContingenciesDisclosureAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Commitments And Contingencies Disclosure [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_UndistributedEarningsLossAvailableToCommonShareholdersDiluted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Undistributed Earnings (Loss) Available to Common Shareholders, Diluted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_UndistributedEarningsLossAvailableToCommonShareholdersDiluted_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net income (loss) attributable to common stockholders</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SaleOfStockConsiderationReceivedOnTransaction_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Consideration to purchaser in cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SaleOfStockConsiderationReceivedOnTransaction_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sale of Stock, Consideration Received on Transaction</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Net Income (Loss) Available to Common Stockholders, Basic</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net income (loss) attributable to common stockholders - basic</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_StockIssuedDuringPeriodSharesWarrantsExercise_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Stock issued during period shares warrants exercise.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_StockIssuedDuringPeriodSharesWarrantsExercise_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stock Issued During Period Shares Warrants Exercise</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_StockIssuedDuringPeriodSharesWarrantsExercise_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise of Series B Warrants from May 2024 PIPE</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LineOfCredit_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Line of credit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LineOfCredit_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Long-Term Line of Credit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LineOfCredit_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Long-Term Line of Credit, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Total unamortized compensation cost related to outstanding unvested stock options and restricted stock awards</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsFairValueDisclosure_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Assets, Fair Value Disclosure, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsFairValueDisclosure_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Assets, Fair Value Disclosure</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsFairValueDisclosure_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsidiarySaleOfStockAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsidiary Sale Of Stock [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsidiarySaleOfStockAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Sale of Stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Revenues_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Revenues, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Revenues_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Revenues</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Revenues_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Revenue</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Revenues_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Revenue recognized</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Net Cash Provided By Used In Investing Activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net cash used in investing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PrivatePlacementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Private Placement Share [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PrivatePlacementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Private Placement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Undistributed Earnings (Loss) Allocated to Participating Securities, Basic</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesBasic_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Income attributable to 2025 Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_Security12bTitle_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Security12b Title</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_Security12bTitle_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Title of 12(b) Security</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule of Segment Reporting Information, by Segment [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PurchasePriceOfShare_lbl" xlink:role="http://www.xbrl.org/2003/role/label">purchase price of share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PurchasePriceOfShare_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">purchase price of share.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PurchasePriceOfShare_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Purchase price of share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Remained authorized amount for repurchase</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Repurchase Program, Remaining Authorized, Amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cancelled/forfeited (in dollars per share)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MoneyMarketFundsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Money Market Funds [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MoneyMarketFundsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Money Market [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RelatedPartyDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Related and Nonrelated Parties [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RelatedPartyDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Related Party</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MeasurementInputRemainingTermMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Measurement Input Remaining Term [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MeasurementInputRemainingTermMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Measurement input remaining term.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MeasurementInputRemainingTermMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Remaining Term [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class of Warrant or Right [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_LegalEntityAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Legal Entity [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease In Operating Capital [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increases (decreases) in cash caused by changes in operating assets and liabilities:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Balance as of December 31, 2024 (in dollars per share)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Balance as of June 30, 2025 (in dollars per share)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MeasurementInputFairValueOfCommonStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Measurement Input, Fair Value Of Common Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MeasurementInputFairValueOfCommonStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Measurement input, fair value of common stock.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MeasurementInputFairValueOfCommonStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair Value of Common Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Recurring and Nonrecurring [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdditionalPaidInCapitalMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additional Paid In Capital [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdditionalPaidInCapitalMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additional Paid-in Capital [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RegularPurchasePricePerShareThresholdPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Regular Purchase Price Per Share Threshold Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RegularPurchasePricePerShareThresholdPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Regular purchase price per share threshold percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RegularPurchasePricePerShareThresholdPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Regular purchase price per share threshold percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementFrequencyDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Measurement Frequency [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_StockRepurchaseProgramAuthorizedAmount1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Repurchase Program, Authorized, Amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_StockRepurchaseProgramAuthorizedAmount1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Authorized amount of repurchase of stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncomeStatementLocationAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement of Income Location, Balance [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">New Accounting Pronouncements or Change in Accounting Principle [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ChangeInAccountingPrincipleAccountingStandardsUpdateAdoptionDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Change in accounting principle, accounting standards update, adoption date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ChangeInAccountingPrincipleAccountingStandardsUpdateAdoptionDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Change in Accounting Principle, Accounting Standards Update, Adoption Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_TradingSymbol_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Trading Symbol</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_TradingSymbol_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Trading Symbol</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventTypeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsequent Event Type [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FloorPrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Floor Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FloorPrice_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Floor price.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FloorPrice_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Floor price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Net Cash Provided By Used In Financing Activities [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash flows provided by financing activities:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementsRecurringMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Recurring [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementsRecurringMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Recurring Basis [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AccruedLicensePayable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accrued payments due to NanoTx</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AccruedLicensePayable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accrued License Payable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AccruedLicensePayable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Accrued license payable.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Measurement Inputs and Valuation Techniques [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementEquityComponentsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Equity Components [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementEquityComponentsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement Equity Components [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementEquityComponentsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Equity Components</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LinesOfCreditCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Line of credit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LinesOfCreditCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Line of Credit, Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NonoperatingIncomeExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Nonoperating Income Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NonoperatingIncomeExpense_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Interest expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NonoperatingIncomeExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NonoperatingIncomeExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total other income (expense)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EquityComponentDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Equity Component [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EquityComponentDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Component [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EquityComponentDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Equity Component</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfShareBasedCompensationActivityTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Share Based Compensation Activity Table [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfShareBasedCompensationActivityTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock Option Activity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Investments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Total investments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Investments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Investments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Investments_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Investments, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_BioceptAssetAcquisitionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Biocept Asset Acquisitions [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_BioceptAssetAcquisitionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Biocept asset acquisitions.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInOtherCurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease In Other Current Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInOtherCurrentAssets_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Other current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PrepaidInsurance_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Prepaid insurance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PrepaidInsurance_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Prepaid Insurance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_GrossProceedsFromIssuanceOfCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Gross Proceeds from Issuance of Common Stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_GrossProceedsFromIssuanceOfCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Gross proceeds from issuance of common stock.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_GrossProceedsFromIssuanceOfCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Aggregate gross proceeds from sales of common stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareDilutedLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Earnings Per Share, Diluted, by Common Class, Including Two Class Method [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sharebased Compensation Arrangement By Sharebased Payment Award Expiration Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock option contractual term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MarchTwoThousandTwentyFiveSeriesAWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">March Two Thousand Twenty Five Series A Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MarchTwoThousandTwentyFiveSeriesAWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">March Two Thousand Twenty Five Series A Warrants Member.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MarchTwoThousandTwentyFiveSeriesAWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">March 2025 Series A Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_DepartmentOfDefenseAwardMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Department of Defense Award [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_DepartmentOfDefenseAwardMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Department of defense award.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_MaximumMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maximum [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_MaximumMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Maximum [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_RangeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Statistical Measurement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_RangeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Statistical Measurement [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_RangeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Range [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockValue_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Common stock, $0.001 par value; 100,000,000 shares authorized; 36,123,833 and 33,601,373 issued and outstanding at March 31, 2023 and December 31, 2022, respectively</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockValue_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Voting stock, value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock, $0.001 par value; 2,000,000,000 shares authorized; 92,438,432 shares issued; and 92,180,007 shares outstanding as of June 30, 2025, and 100,000,00 shares authorized; 6,154,758 shares issued; and 5,896,333 shares outstanding as of December 31, 2024, respectively</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Net Income (Loss) Available to Common Stockholders, Diluted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net loss per share of common stock - diluted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MarchTwoThousandTwentyFiveSeriesAWarrantsAndSeriesBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">March 2025 Series A and Series B Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MarchTwoThousandTwentyFiveSeriesAWarrantsAndSeriesBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">March Two Thousand Twenty Five Series A Warrants and Series B Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MarchTwoThousandTwentyFiveSeriesAWarrantsAndSeriesBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">March 2025 Series A and March 2025 Series B common stock warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_LincolnParkPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lincoln Park Purchase Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_LincolnParkPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Lincoln Park Purchase Agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_LincolnParkPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Lincoln Park Purchase Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MinimumBidRequirementDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Minimum Bid Requirement Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MinimumBidRequirementDate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Minimum bid requirement date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MinimumBidRequirementDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Minimum bid requirement date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockSharesAuthorized_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock Shares Authorized</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockSharesAuthorized_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Preferred stock, shares authorized (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IssuanceOfCommonStockSharesPrefundedWarrantsAndWarrantsNetOfOfferingCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Issuance of common stock, prefunded warrants and warrants, net of offering costs (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IssuanceOfCommonStockSharesPrefundedWarrantsAndWarrantsNetOfOfferingCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Issuance Of Common Stock Shares, Prefunded Warrants And Warrants, Net Of Offering Costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_IssuanceOfCommonStockSharesPrefundedWarrantsAndWarrantsNetOfOfferingCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Issuance of common stock shares, prefunded warrants and warrants, net of offering costs.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FebruaryTwoThousandTwentyFiveWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">February Two Thousand Twenty Five Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FebruaryTwoThousandTwentyFiveWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">February two thousand twenty five warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FebruaryTwoThousandTwentyFiveWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">February 2025 Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfCommissionOnGrossProceedsFromSaleOfCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of commission on gross proceeds from sale of common stock.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfCommissionOnGrossProceedsFromSaleOfCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of Commission on Gross Proceeds from Sale of Common Stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfCommissionOnGrossProceedsFromSaleOfCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of commission on gross proceeds from sale of common stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RevenueFromContractWithCustomerTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Revenue from Contract with Customer [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RevenueFromContractWithCustomerTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Grant Revenue</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityRegistrantName_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Registrant Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityRegistrantName_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Entity Registrant Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherDeferredCostsNet_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Deferred Costs, Net</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherDeferredCostsNet_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Other Deferred Costs, Net, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherDeferredCostsNet_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred costs (Note 7)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AdditionalPeriodForRegainComplianceOnAchievementOfCompliance_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additional Period for Regain Compliance on Achievement of Compliance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AdditionalPeriodForRegainComplianceOnAchievementOfCompliance_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Additional period for regain compliance on achievement of compliance.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AdditionalPeriodForRegainComplianceOnAchievementOfCompliance_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additional period for regain compliance on achievement of compliance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesBWarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series B Warrant [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesBWarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Series B Warrant.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PersonnelRelatedExpensesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Personnel Related Expenses [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PersonnelRelatedExpensesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Personnel Related Expenses [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockSharesAcquired_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Purchase of treasury stock (in Shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockSharesAcquired_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Treasury Stock, Shares, Acquired</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TreasuryStockSharesAcquired_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Purchase of treasury stock (in Shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FinancingExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financing expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FinancingExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financing Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FinancingExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Financing expenses.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_FinancingExpenses_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Financing expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdditionalPaidInCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additional Paid In Capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdditionalPaidInCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additional paid-in capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdditionalPaidInCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Additional Paid in Capital, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AmendmentAndRestatementsMay2024PrivatePlacementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Amendment and Restatements May 2024 Private Placement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_AmendmentAndRestatementsMay2024PrivatePlacementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Amendment and restatements May 2024 private placement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsequent Events [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accounts Payable And Accrued Liabilities Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accounts payable and accrued expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Accounts payable and accrued expenses, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueByMeasurementFrequencyAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Measurement Frequency [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsToAcquireProductiveAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Total cash payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsToAcquireProductiveAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Payments to Acquire Productive Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsToAcquireProductiveAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Payments to Acquire Productive Assets, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsToAcquireProductiveAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Total cash payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromIssuanceOfCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds from Issuance of Common Stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromIssuanceOfCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from sale of common stock under Lincoln Park Purchase Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromIssuanceOfCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Cash proceeds from sale of common stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SubscriptionAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Subscription and Investment Representation Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SubscriptionAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subscription Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SubscriptionAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Subscription Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Share Based Compensation Arrangement By Share Based Payment Award [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Key Level 3 Inputs Used in Valuation of Warrants Liability at Fair Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_UseOfEstimatesTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Provides an entity's explanation that the preparation of financial statements in conformity with generally accepted accounting principles requires the use of management estimates.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_UseOfEstimatesTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Use Of Estimates [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_UseOfEstimatesTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Use of Estimates</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCommonStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Common Stock Shares Outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCommonStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Common Stock, Shares Outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_UnpaidOfferingCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Unpaid Offering Costs.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_UnpaidOfferingCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Unpaid Offering Costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_UnpaidOfferingCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Unpaid offering cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueByLiabilityClassAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liability Class [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MeasurementInputInterestRateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Measurement Input Interest Rate [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MeasurementInputInterestRateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Measurement input interest rate.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_MeasurementInputInterestRateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest Rate [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Payments To Acquire Property Plant And Equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Purchases of property and equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Payments to Acquire Property, Plant, and Equipment, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Assets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Assets_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercisable at June 30, 2025</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncomeStatementAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Income Statement [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SecuritiesPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Securities Purchase Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SecuritiesPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Securities purchase agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SecuritiesPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Securities Purchase Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LegalFees_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Legal Fees</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LegalFees_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Legal fees</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of shares issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sale of Stock, Number of Shares Issued in Transaction</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesAWarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Series A Warrant.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_SeriesAWarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series A Warrant [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesNewIssues_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sale of common stock, net</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesNewIssues_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Issue and sale of share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesNewIssues_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Issuance of common stock (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareDiluted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Earnings Per Share Diluted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareDiluted_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net loss per share, diluted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareDiluted_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Net loss per share of common stock - diluted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule of Segment Reporting Information, by Segment [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule of Segment Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetAcquisitionAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Asset Acquisition [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CityAreaCode_lbl" xlink:role="http://www.xbrl.org/2003/role/label">City Area Code</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CityAreaCode_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">City Area Code</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RedemptionOfNotesByIssuanceOfCommonStockPrefundedWarrantsAndWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Redemption of Notes by Issuance of Common Stock, Prefunded Warrants and Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RedemptionOfNotesByIssuanceOfCommonStockPrefundedWarrantsAndWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Redemption of notes by issuance of common stock, prefunded warrants and warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_RedemptionOfNotesByIssuanceOfCommonStockPrefundedWarrantsAndWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Redemption of notes by issuance of common stock, pre-funded warrants and warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromLinesOfCredit_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from credit facility</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromLinesOfCredit_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds from Lines of Credit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromLinesOfCredit_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Proceeds from Lines of Credit, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentFaceAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Original loan amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentFaceAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Aggregate principal amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentFaceAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Debt Instrument Face Amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NonCashFinancingExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-Cash Financing Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NonCashFinancingExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non-cash financing expense.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NonCashFinancingExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Noncash financing expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfCashlessWarrantsExcercisedForCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cashless warrants excercised for common stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfCashlessWarrantsExcercisedForCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of Cashless Warrants Excercised for Common Stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfCashlessWarrantsExcercisedForCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of cashless warrants excercised for common stock.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SegmentReportingInformationLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Segment Reporting Information [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock split conversion ratio</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stockholders' Equity Note, Stock Split, Conversion Ratio</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LeaseExpirationDate1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lease Expiration Date1</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LeaseExpirationDate1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating leases, expiration date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfPreferredStockSharesExercised_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number Of Preferred Stock Shares Exercised.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfPreferredStockSharesExercised_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Preferred Stock Shares Exercised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_NumberOfPreferredStockSharesExercised_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of preferred stock, shares converted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PropertyPlantAndEquipmentNet_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Property Plant And Equipment Net</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PropertyPlantAndEquipmentNet_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Property and equipment, net</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PropertyPlantAndEquipmentNet_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Property, Plant and Equipment, Net, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Cash and cash equivalents at end of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Cash and cash equivalents at beginning of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingIncomeLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Income Loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingIncomeLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Operating loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfCreditFacilityCannotExceedCollateralizedMarketableSecurities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of credit facility cannot exceed collateralized marketable securities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfCreditFacilityCannotExceedCollateralizedMarketableSecurities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of Credit Facility Cannot Exceed Collateralized Marketable Securities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="pstv_PercentageOfCreditFacilityCannotExceedCollateralizedMarketableSecurities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of credit facility cannot exceed collateralized marketable securities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RetainedEarningsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Retained Earnings [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RetainedEarningsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accumulated Deficit [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashAndCashEquivalentsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash and Cash Equivalents [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensation_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Share-based compensation expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensation_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensation_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Share-Based Payment Arrangement, Noncash Expense, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MeasurementInputPriceVolatilityMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Measurement Input, Price Volatility [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MeasurementInputPriceVolatilityMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Volatility [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsOfStockIssuanceCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Payments of Stock Issuance Costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsOfStockIssuanceCosts_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Costs from sale of common stock</link:label>
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  <xsd:element id="pstv_ProceedsFromGrantsReceived" name="ProceedsFromGrantsReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
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  <xsd:element id="pstv_AmountToBeReceivedAsAwardForResearchAndDevelopment" name="AmountToBeReceivedAsAwardForResearchAndDevelopment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
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  <xsd:element id="pstv_RestrictedBeneficialOwnershipLevelResultOfExerciseOfWarrantToReceivePreFundedWarrant" name="RestrictedBeneficialOwnershipLevelResultOfExerciseOfWarrantToReceivePreFundedWarrant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_SupportLetterParticipationRightsPeriod" name="SupportLetterParticipationRightsPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_StockBasedCompensation2020EquityIncentivePlanMember" name="StockBasedCompensation2020EquityIncentivePlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
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  <xsd:element id="pstv_PercentageOfNonDilutiveMonetaryAwardsRequiredToPay" name="PercentageOfNonDilutiveMonetaryAwardsRequiredToPay" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_LicenseAgreementAbstract" name="LicenseAgreementAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_May2024PrivatePlacementMember" name="May2024PrivatePlacementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
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  <xsd:element id="pstv_CpritGrantFundingTerm" name="CpritGrantFundingTerm" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_ResearchAndDevelopmentAwardInPeriod" name="ResearchAndDevelopmentAwardInPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsCancelledOrForfeitedInPeriodTotalIntrinsicValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsCancelledOrForfeitedInPeriodTotalIntrinsicValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
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  <xsd:element id="pstv_MayTwoThousandTwentyFourSeriesAWarrantsMember" name="MayTwoThousandTwentyFourSeriesAWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
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  <xsd:element id="pstv_PercentageOfCreditFacilityCannotExceedCollateralizedMarketableSecurities" name="PercentageOfCreditFacilityCannotExceedCollateralizedMarketableSecurities" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_UseOfEstimatesAbstract" name="UseOfEstimatesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
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  <xsd:element id="pstv_IssuanceOfCommonStockPrefundedWarrantsAndWarrantsForDebtRepayment" name="IssuanceOfCommonStockPrefundedWarrantsAndWarrantsForDebtRepayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
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  <xsd:element id="pstv_StockIssuedDuringPeriodSharesWarrantsExerciseShares" name="StockIssuedDuringPeriodSharesWarrantsExerciseShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_WarrantsPolicyPolicyTextBlock" name="WarrantsPolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_PercentageOfGrantProceedsWithInterestNotExceedAnnually" name="PercentageOfGrantProceedsWithInterestNotExceedAnnually" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_SPEAWarrantsMember" name="SPEAWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_ConsiderationPaidToPreferredStockHolders" name="ConsiderationPaidToPreferredStockHolders" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
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  <xsd:element id="pstv_StockBasedCompensation2015EquityIncentivePlan1Member" name="StockBasedCompensation2015EquityIncentivePlan1Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_CompositionOfCertainFinancialStatementCaptionsAbstract" name="CompositionOfCertainFinancialStatementCaptionsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
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  <xsd:element id="pstv_PercentageOfProceedsToRepayPurchasersFromCapitalRaised" name="PercentageOfProceedsToRepayPurchasersFromCapitalRaised" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_ChangeInFairValueOfWarrants" name="ChangeInFairValueOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="pstv_MaximumValueOfSharesToBeIssuedUnderAgreement" name="MaximumValueOfSharesToBeIssuedUnderAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_SecuritiesPurchaseAgreementMember" name="SecuritiesPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_PersonnelRelatedExpensesMember" name="PersonnelRelatedExpensesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_MaximumBeneficialOwnershipPercentageByElectionOfHolder" name="MaximumBeneficialOwnershipPercentageByElectionOfHolder" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_LetterAgreementMember" name="LetterAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_PrivatePlacementAndPrefundedWarrantMember" name="PrivatePlacementAndPrefundedWarrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_ProfessionalExpensesMember" name="ProfessionalExpensesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_InitialCommitmentFee" name="InitialCommitmentFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_AdditionalCommitmentFee" name="AdditionalCommitmentFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_CharlottesvilleMember" name="CharlottesvilleMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_NumberOfWarrantsExercised" name="NumberOfWarrantsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_DepartmentOfDefenseAwardMember" name="DepartmentOfDefenseAwardMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_RedemptionOfShortTermInvestments" name="RedemptionOfShortTermInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="pstv_IssuanceOfCommonStockSharesPrefundedWarrantsAndWarrantsNetOfOfferingCosts" name="IssuanceOfCommonStockSharesPrefundedWarrantsAndWarrantsNetOfOfferingCosts" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_ClosingStockPriceNotBelowZeroPointSevenFiveMember" name="ClosingStockPriceNotBelowZeroPointSevenFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
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  <xsd:element id="pstv_PreferredStockDividendRatePercentageEliminatedDate" name="PreferredStockDividendRatePercentageEliminatedDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_ExchangeOfWarrantForNotesPayable" name="ExchangeOfWarrantForNotesPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_BioceptAssetAcquisitionsMember" name="BioceptAssetAcquisitionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
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  <xsd:element id="pstv_ConsecutiveBusinessDays" name="ConsecutiveBusinessDays" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_DisclosureOfLiquidityAndGoingConcernTextBlock" name="DisclosureOfLiquidityAndGoingConcernTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_FairValueOfWarrantLiabilityReclassifiedToEquity" name="FairValueOfWarrantLiabilityReclassifiedToEquity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
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  <xsd:element id="pstv_LincolnParkPurchaseAgreementMember" name="LincolnParkPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_ExchangeOfWarrantsForNotesPayable" name="ExchangeOfWarrantsForNotesPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_NumberOfSharesIssuableUponExercise" name="NumberOfSharesIssuableUponExercise" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="pstv_TwoThousandEighteenRightsOfferingMember" name="TwoThousandEighteenRightsOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_MarchTwoThousandTwentyFiveSeriesBWarrantsMember" name="MarchTwoThousandTwentyFiveSeriesBWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityReclassifiedToEquity" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityReclassifiedToEquity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="pstv_WarrantLiabilityNoncurrent" name="WarrantLiabilityNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityModificationAndExtinguishment" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityModificationAndExtinguishment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="pstv_ClosingStockPriceNotBelowZeroPointFiveZeroMember" name="ClosingStockPriceNotBelowZeroPointFiveZeroMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_StockIssuedDuringPeriodSharesExerciseOfSeriesBWarrants" name="StockIssuedDuringPeriodSharesExerciseOfSeriesBWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_SeriesAWarrantsMember" name="SeriesAWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_MaximumBeneficialOwnershipPercentage" name="MaximumBeneficialOwnershipPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_ExchangeNotesMember" name="ExchangeNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_NewCapitalSubscriptionsMember" name="NewCapitalSubscriptionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_ConvertibleNotesTerm" name="ConvertibleNotesTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="pstv_PercentageOfLiquidatedDamagesObligatedToPay" name="PercentageOfLiquidatedDamagesObligatedToPay" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_CancerPreventionAndResearchInstituteOfTexasContractMember" name="CancerPreventionAndResearchInstituteOfTexasContractMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_FundingNotesMember" name="FundingNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_ProceedsFromSaleOfCommonStockPrefundedWarrantsAndWarrants" name="ProceedsFromSaleOfCommonStockPrefundedWarrantsAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="pstv_PreClinicalResearchStudyObligationsMember" name="PreClinicalResearchStudyObligationsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_AdditionalPeriodForRegainComplianceOnAchievementOfCompliance" name="AdditionalPeriodForRegainComplianceOnAchievementOfCompliance" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_MayTwoThousandTwentyFourSeriesBWarrantsMember" name="MayTwoThousandTwentyFourSeriesBWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_RemeasurementOfWarrantLiability" name="RemeasurementOfWarrantLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_NumberOfMaximumCommonSharesCanBeResale" name="NumberOfMaximumCommonSharesCanBeResale" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="pstv_MinimumStockholdersEquityRequirementDate" name="MinimumStockholdersEquityRequirementDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_SeriesBConvertiblePreferredStockMember" name="SeriesBConvertiblePreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_NumberOfPreferredStockSharesExercised" name="NumberOfPreferredStockSharesExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_SeriesFConvertiblePreferredStockMember" name="SeriesFConvertiblePreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_MarchTwoThousandTwentyFiveSeriesAWarrantsAndSeriesBWarrantsMember" name="MarchTwoThousandTwentyFiveSeriesAWarrantsAndSeriesBWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_GrossProceedsFromIssuanceOfCommonStock" name="GrossProceedsFromIssuanceOfCommonStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="pstv_ExchangeMember" name="ExchangeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_GrantFundingTerm" name="GrantFundingTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_MarchTwoThousandTwentyFivePrefundedWarrantsMember" name="MarchTwoThousandTwentyFivePrefundedWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_MarchTwoThousandTwentyFiveSeriesAAndBWarrantsMember" name="MarchTwoThousandTwentyFiveSeriesAAndBWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_AcceleratedPurchasePricePerShareThresholdPercentage" name="AcceleratedPurchasePricePerShareThresholdPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_MaintainMinimumMarketValueOfListedSecurities" name="MaintainMinimumMarketValueOfListedSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="pstv_ClosingStockPriceNotBelowZeroPointOneZeroMember" name="ClosingStockPriceNotBelowZeroPointOneZeroMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_SeriesAWarrantMember" name="SeriesAWarrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_MeasurementInputFairValueOfCommonStockMember" name="MeasurementInputFairValueOfCommonStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_SeriesAWarrantAndSeriesBWarrantMember" name="SeriesAWarrantAndSeriesBWarrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_MaximumObligationUnderSingleRegularPurchase" name="MaximumObligationUnderSingleRegularPurchase" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_PercentageOfAggregateAmountOfProceedsAwardedUnderCpritGrant" name="PercentageOfAggregateAmountOfProceedsAwardedUnderCpritGrant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_InitialCommitmentShares" name="InitialCommitmentShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="pstv_SubscriptionAgreementMember" name="SubscriptionAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_ConvertibleNotesMember" name="ConvertibleNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_SeriesBWarrantMember" name="SeriesBWarrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_WarrantIssuanceExpenses" name="WarrantIssuanceExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="pstv_PercentageOfCommissionOnGrossProceedsFromSaleOfCommonStock" name="PercentageOfCommissionOnGrossProceedsFromSaleOfCommonStock" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_MeasurementInputInterestRateMember" name="MeasurementInputInterestRateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_AccruedLicensePayable" name="AccruedLicensePayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_ChangeInFairValueOfDerivativeInstruments" name="ChangeInFairValueOfDerivativeInstruments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="pstv_FinancingPercentageAfterModificationPeriod" name="FinancingPercentageAfterModificationPeriod" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_IncreaseDecreaseInDeferredGrantLiability" name="IncreaseDecreaseInDeferredGrantLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="pstv_ClosingBidPriceForCommonStockHadFallenBelow" name="ClosingBidPriceForCommonStockHadFallenBelow" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_ClassOfWarrantOrRightWarrantsExerciseRatio" name="ClassOfWarrantOrRightWarrantsExerciseRatio" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="pstv_LincolnParkCapitalFundLLCMember" name="LincolnParkCapitalFundLLCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_PrefundedWarrantMember" name="PrefundedWarrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_UseOfEstimatesTextBlock" name="UseOfEstimatesTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_FirstPaymentReceived" name="FirstPaymentReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="pstv_NetOfOfferingCosts" name="NetOfOfferingCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="pstv_FebruaryTwoThousandTwentyFiveSecuritiesPurchaseAndExchangeAgreementsMember" name="FebruaryTwoThousandTwentyFiveSecuritiesPurchaseAndExchangeAgreementsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_NumberOfCashlessWarrantsExcercisedForCommonStock" name="NumberOfCashlessWarrantsExcercisedForCommonStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_RegainComplianceExpiryDate" name="RegainComplianceExpiryDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_RegularPurchasePricePerShareThresholdPercentage" name="RegularPurchasePricePerShareThresholdPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_IssuanceOfCommonStockSharesPrefundedWarrantsAndWarrantsForDebtRepayment" name="IssuanceOfCommonStockSharesPrefundedWarrantsAndWarrantsForDebtRepayment" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_PercentageAgreedToRepayPurchasersHoldingSecurities" name="PercentageAgreedToRepayPurchasersHoldingSecurities" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_DebtInstrumentFloorRate" name="DebtInstrumentFloorRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_NumberOfVotesPerShare" name="NumberOfVotesPerShare" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="pstv_NonCashFinancingExpense" name="NonCashFinancingExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="pstv_CongressionallyDirectedMedicalResearchProgramsMember" name="CongressionallyDirectedMedicalResearchProgramsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_RightsRelatedToDistributionOfAssets" name="RightsRelatedToDistributionOfAssets" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_PershingCreditFacilityMember" name="PershingCreditFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_MayTwoThousandTwentyFourPurchaseAgreementMember" name="MayTwoThousandTwentyFourPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_ExerciseOfPreFundedWarrantsShares" name="ExerciseOfPreFundedWarrantsShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_StockIssuedDuringPeriodValueExerciseOfSeriesBWarrants" name="StockIssuedDuringPeriodValueExerciseOfSeriesBWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="pstv_ExerciseOfPreFundedWarrants" name="ExerciseOfPreFundedWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_SeriesCConvertiblePreferredStockMember" name="SeriesCConvertiblePreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_PotentialCashPayment" name="PotentialCashPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_OfferingCosts" name="OfferingCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="pstv_AdjustmentsToAdditionalPaidInCapitalModificationOfWarrants" name="AdjustmentsToAdditionalPaidInCapitalModificationOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_IssuanceOfCommonStockPrefundedWarrantsAndWarrantsNetOfOfferingCosts" name="IssuanceOfCommonStockPrefundedWarrantsAndWarrantsNetOfOfferingCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_NanoTxLicensesAgreementMember" name="NanoTxLicensesAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_CashPaidDuringPeriodForAbstract" name="CashPaidDuringPeriodForAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_PotentialLiquidatedDamagesPaymentLiability" name="PotentialLiquidatedDamagesPaymentLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_StockIssuedDuringPeriodValueReclassificationOfWarrantsToEquity" name="StockIssuedDuringPeriodValueReclassificationOfWarrantsToEquity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_WarrantLiabilities" name="WarrantLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="pstv_AmendmentAndRestatementsMay2024PrivatePlacementMember" name="AmendmentAndRestatementsMay2024PrivatePlacementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_FacilityAndOtherOverheadExpensesMember" name="FacilityAndOtherOverheadExpensesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_ManufacturingAgreementWithSpectronRXMember" name="ManufacturingAgreementWithSpectronRXMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_SeriesAConvertiblePreferredStockMember" name="SeriesAConvertiblePreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_MinimumBidRequirementDate" name="MinimumBidRequirementDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_PotentialFinancingPercentage" name="PotentialFinancingPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_ClinicalDevelopmentAndLicensingExpensesMember" name="ClinicalDevelopmentAndLicensingExpensesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="pstv_ContractTerminationDate" name="ContractTerminationDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_PeriodExercisableFromTheDateOfIssuance" name="PeriodExercisableFromTheDateOfIssuance" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="pstv_WarrantIssuanceCosts" name="WarrantIssuanceCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="pstv_MeasurementInputRemainingTermMember" name="MeasurementInputRemainingTermMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
</xsd:schema>
