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As filed with the Securities and Exchange Commission on February 10, 2005

Registration No. 333-            



SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549


FORM S-8

REGISTRATION STATEMENT
UNDER THE SECURITIES ACT OF 1933


MACROPORE BIOSURGERY, INC.
(Exact Name of Registrant as Specified in its Charter)

Delaware       33-0827593
(State or Other Jurisdiction
of Incorporation or Organization)
      (I.R.S. Employer Identification No.)

6740 Top Gun Street
San Diego, California 92121
(Address of Principal Executive Offices)

2004 EQUITY INCENTIVE PLAN
(Full Title of the Plan)

Christopher J. Calhoun
Chief Executive Officer and Vice-Chairman of the Board
6740 Top Gun Street
San Diego, California 92121
Telephone: (858) 458-0900
(Name and Address of Agent For Service)

Copy to:
Hayden J. Trubitt, Esq.
HELLER EHRMAN WHITE & MCAULIFFE LLP
4350 La Jolla Village Drive, 7th Floor
San Diego, California 92122-1246
Telephone: (858) 450-8400
Facsimile: (858) 450-8499

CALCULATION OF REGISTRATION FEE


Title of Each Class
of Securities to be Registered

  Amount to be
Registered(1)

  Proposed Maximum
Offering Price
per Share(2)

  Proposed Maximum
Aggregate
Offering Price(2)

  Amount of
Registration
Fee


Common Stock, par value $0.001 per share   3,000,000   $3.0248   $9,074,400   $1,068.06

(1)
This registration statement shall also cover any additional shares of the registrant's common stock that become issuable by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the registrant's receipt of consideration that results in an increase in the number of the registrant's outstanding shares of common stock.

(2)
Estimated solely for the purpose of computing the registration fee pursuant to Rule 457(h) under the Securities Act of 1933 and based on the average of the high and low sale prices of the registrant's common stock on February 3, 2005, as reported on the Frankfurt Stock Exchange, which average was 2.32 Euros, or $3.0248 per share, based on the exchange rate in effect as of such date.





Part I

INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

        The documents containing the information specified in Part I will be sent or given to employees as specified by Rule 428(b)(1). Such documents are not being filed with the Securities and Exchange Commission (the "Commission") either as part of this registration statement or as prospectuses or prospectus supplements pursuant to Rule 424. Such documents and the documents incorporated by reference in this Registration Statement pursuant to Item 3 of Part II of this registration statement, taken together, constitute a prospectus that meets the requirements of Section 10(a) of the Securities Act.


Part II

INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.    Incorporation of Documents by Reference.

        The following documents, which we have filed with or furnished to the Securities and Exchange Commission (the "Commission"), are incorporated herein by reference and made a part hereof:

        All documents subsequently filed by us pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934 (the "Exchange Act"), prior to the filing of a post-effective amendment to this registration statement indicating that all securities offered hereby have been sold or deregistering all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part hereof from the date of filing of such documents. Any statement contained herein or in any document incorporated or deemed to be incorporated by reference herein shall be

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deemed to be modified or superseded for purposes of this registration statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed to constitute a part of this registration statement, except as so modified or superseded.


Item 4.    Description of Securities.

        Not applicable.


Item 5.    Interests of Named Experts and Counsel.

        Not applicable.


Item 6.    Indemnification of Directors and Officers.

        Section 145 of the Delaware General Corporation Law permits us to indemnify our directors, officers, employees or agents under certain conditions and subject to certain limitations. Section 145 of the Delaware General Corporation Law also permits us to purchase and maintain insurance on behalf of our directors, officers, employees or agents against any liability asserted against them and incurred by them arising out of their capacity or status as our directors, officers, employees or agents whether or not we would have the power to indemnify them against such liability under the provisions of Section 145 of the Delaware General Corporation Law.

        Our Amended and Restated Certificate of Incorporation reduces the liability of our directors to us and our stockholders for monetary damages for any breach of their fiduciary duties as our directors to the fullest extent permitted by the Delaware General Corporation Law. Our Amended and Restated Certificate of Incorporation and our Amended and Restated Bylaws further provide for indemnification of our directors, officers, employees and agents to the fullest extent permitted by the Delaware General Corporation Law.


Item 7.    Exemption from Registration Claimed.

        Not applicable.

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Item 8.    Exhibits.

Exhibit
No.

  Description
4.1   Amended and Restated Certificate of Incorporation(1)

4.2

 

Amended and Restated Bylaws(2)

4.3

 

Rights Agreement, dated as of May 19, 2003, with Computershare Trust Company, Inc. as Rights Agent, which includes: as Exhibit A thereto, the Form of Certificate of Designation, Preferences and Rights of our Series RP Preferred Stock; as Exhibit B thereto, the Form of Right Certificate; and, as Exhibit C thereto, the Summary of Rights to Purchase our Series RP Preferred Stock(3)

5.1

 

Opinion of Heller Ehrman White & McAuliffe LLP*

23.1

 

Consent of Independent Registered Public Accounting Firm, KPMG LLP*

23.2

 

Consent of Heller Ehrman White & McAuliffe LLP (filed as a part of Exhibit 5.1)*

24.1

 

Power of Attorney (included in the signature page to this registration statement)*

99.1

 

2004 Equity Incentive Plan(4)

99.2

 

Form of Notice of Stock Options Grant Relating to the 2004 Equity Incentive Plan(5)

99.3

 

Form of Options Exercise and Stock Purchase Agreement Relating to the 2004 Equity Incentive Plan(5)

*
Filed herewith.

(1)
This exhibit was filed as a part of, and is hereby incorporated by reference to our quarterly report on Form 10-Q, filed with the Commission on August 13, 2002.

(2)
This exhibit was filed as a part of, and is hereby incorporated by reference to our quarterly report on Form 10-Q for the quarter ended June 30, 2003, filed with the Commission on August 14, 2003.

(3)
This exhibit was filed as a part of, and is hereby incorporated by reference to our registration statement on Form 8-A, filed with the Commission on May 30, 2003.

(4)
This exhibit was filed as part of, and is hereby incorporated by reference to our current report on Form 8-K, filed with the Commission on August 27, 2004.

(5)
This exhibit was filed as part of, and is hereby incorporated by reference to our quarterly report on Form 10-Q for the quarter ended September 30, 2004, filed with the Commission on November 15, 2004.


Item 9.    Undertakings.

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*    *    *

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SIGNATURES

        Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of San Diego, state of California, on this 10th day of February 2005.

    MACROPORE BIOSURGERY, INC.

 

 

By:

/s/  
CHRISTOPHER J. CALHOUN      
Christopher J. Calhoun
Chief Executive Officer and Vice Chairman of the Board


POWER OF ATTORNEY

        KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Christopher J. Calhoun as his true and lawful attorney-in-fact and agent, with full power of substitution, for him in any and all capacities, to sign any and all amendments to this registration statement on Form S-8 and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent, with full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he/she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitutes, may lawfully do or cause to be done by virtue hereof.

        Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities indicated on the dates set forth below.

Signature
  Title
  Date

 

 

 

 

 
/s/  MARSHALL G. COX      
Marshall G. Cox
  Chairman of the Board of Directors and Director   February 10, 2005

/s/  
CHRISTOPHER J. CALHOUN      
Christopher J. Calhoun

 

Chief Executive Officer, Vice-Chairman of the Board and Director (Principal Executive Officer)

 

February 10, 2005

/s/  
MARC H. HEDRICK, M.D.      
Marc H. Hedrick, M.D.

 

President and Director

 

February 10, 2005

/s/  
MARK E. SAAD      
Mark E. Saad

 

Chief Financial Officer (Principal Financial Officer)

 

February 10, 2005

/s/  
CHARLES E. GALETTO      
Charles E. Galetto

 

Senior Vice President of Finance (Principal Accounting Officer)

 

February 10, 2005

/s/  
DAVID M. RICKEY      
David M. Rickey

 

Director

 

February 10, 2005

/s/  
RONALD D. HENRIKSEN      
Ronald D. Henriksen

 

Director

 

February 10, 2005


E. Carmack Holmes, M.D.

 

Director

 

 

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EXHIBIT INDEX

Exhibit
No.

  Description
4.1   Amended and Restated Certificate of Incorporation(1)

4.2

 

Amended and Restated Bylaws(2)

4.3

 

Rights Agreement, dated as of May 19, 2003, with Computershare Trust Company, Inc. as Rights Agent, which includes: as Exhibit A thereto, the Form of Certificate of Designation, Preferences and Rights of our Series RP Preferred Stock; as Exhibit B thereto, the Form of Right Certificate; and, as Exhibit C thereto, the Summary of Rights to Purchase our Series RP Preferred Stock(3)

5.1

 

Opinion of Heller Ehrman White & McAuliffe LLP*

23.1

 

Consent of Independent Registered Public Accounting Firm, KPMG LLP*

23.2

 

Consent of Heller Ehrman White & McAuliffe LLP (filed as a part of Exhibit 5.1)*

24.1

 

Power of Attorney (included in the signature page to this registration statement)*

99.1

 

2004 Equity Incentive Plan(4)

99.2

 

Form of Notice of Stock Options Grant Relating to the 2004 Equity Incentive Plan(5)

99.3

 

Form of Options Exercise and Stock Purchase Agreement Relating to the 2004 Equity Incentive Plan(5)

*
Filed herewith.

(1)
This exhibit was filed as a part of, and is hereby incorporated by reference to our quarterly report on Form 10-Q, filed with the Commission on August 13, 2002.

(2)
This exhibit was filed as a part of, and is hereby incorporated by reference to our quarterly report on Form 10-Q for the quarter ended June 30, 2003, filed with the Commission on August 14, 2003.

(3)
This exhibit was filed as a part of, and is hereby incorporated by reference to our registration statement on Form 8-A, filed with the Commission on May 30, 2003.

(4)
This exhibit was filed as part of, and is hereby incorporated by reference to our current report on Form 8-K, filed with the Commission on August 27, 2004.

(5)
This exhibit was filed as part of, and is hereby incorporated by reference to our quarterly report on Form 10-Q for the quarter ended September 30, 2004, filed with the Commission on November 15, 2004.



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Part I INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
Part II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
SIGNATURES
POWER OF ATTORNEY
EXHIBIT INDEX

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EXHIBIT 5.1

GRAPHIC

February 10, 2005

MacroPore Biosurgery, Inc.
6740 Top Gun Street
San Diego, California 92121

 
 
Re: MacroPore Biosurgery, Inc. Registration Statement on Form S-8 for 3,000,000 Shares of Common Stock Issuable Under the 2004 Equity Incentive Plan

Ladies and Gentlemen:

        We have acted as counsel to MacroPore Biosurgery, Inc., a Delaware corporation (the "Company"), in connection with the registration statement on Form S-8 to be filed with the Securities and Exchange Commission on or about February 10, 2005 (the "Registration Statement"), for the purpose of registering under the Securities Act of 1933, as amended (the "Act"), 3,000,000 shares of the Company's Common Stock (the "Shares"). The Shares are issuable under the Company's 2004 Equity Incentive Plan (the "Plan").

        This opinion is being furnished in accordance with the requirements of Item 8 of Form S-8 and Item 601(b)(5)(i) of Regulation S-K.

        In connection with this opinion, we have assumed the authenticity of all records, documents and instruments submitted to us as originals, the genuineness of all signatures, the legal capacity of natural persons and the conformity to the originals of all records, documents and instruments submitted to us as copies.

        We have reviewed the Company's charter documents and the corporate proceedings taken by the Company in connection with the establishment of the Plan. Based on such review, we are of the opinion that if, as and when the Shares have been issued and sold (and the consideration therefor received) pursuant to (a) the provisions of option agreements duly authorized under the Plan and in accordance with the Registration Statement, or (b) duly authorized direct stock issuances in accordance with the Plan and in accordance with the Registration Statement, such Shares will be duly authorized, legally issued, fully paid and nonassessable.

        This opinion is limited to the federal laws of the United States of America and the General Corporation Law of the State of Delaware. We disclaim any opinion as to the laws of any other jurisdiction. We further disclaim any opinion as to any other statute, rule, regulation, ordinance, order or other promulgation of any other jurisdiction or any regional or local governmental body or as to any related judicial or administrative opinion.

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        We consent to the filing of this opinion letter as Exhibit 5.1 to the Registration Statement. In giving this consent, we do not thereby admit that we are within the category of persons whose consent is required under Section 7 of the Act or the rules and regulations of the Securities and Exchange Commission promulgated thereunder, or Item 509 of Regulation S-K.

        This opinion is rendered to you in connection with the Registration Statement and is solely for your benefit. This opinion may not be relied upon by you for any other purpose, or relied upon by any other person, firm, corporation or other entity for any purpose, without our prior written consent. This opinion letter is rendered as of the date first written above and we disclaim any obligation to advise you of facts, circumstances, events or developments which hereafter may be brought to our attention and which may alter, affect or modify the opinion expressed herein.

 
   
    Very truly yours,

 

 

/s/ Heller Ehrman White & McAuliffe LLP

 

 

 

GRAPHIC




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EXHIBIT 23.1


CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

The Board of Directors
MacroPore Biosurgery, Inc.:

        We consent to the use of our report dated February 20, 2004, with respect to the consolidated balance sheets of MacroPore Biosurgery, Inc. as of December 31, 2003 and 2002, and the related consolidated statements of operations and comprehensive income (loss), stockholders' equity and cash flows for the years then ended, and the related financial statement schedule, which report appears in the December 31, 2003, annual report on Form 10-K of MacroPore Biosurgery, Inc., incorporated herein by reference. Our report refers to the Company deriving a substantial portion of its revenues from a related party.

 
   
/s/ KPMG LLP    

   

San Diego, California
February 7, 2005

 

 



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CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM